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Indomethacin 75 mg capsule twice per day; or tacrolimus (8 mg). 4.4. Pharmacodynamic studies No effect was noted on serum concentrations of total IgG and IgM antibodies to EBOV in 2 patients receiving all of the recommended doses for ≥14 days. The mean serum concentration of total IgG4 was found to be 2.4-fold higher in E-vaccine recipients after 14 days than in placebo recipients Indomethacin 2mg $34.2 - $0.57 Per pill receiving the same daily dose. mean serum concentration of IgM4 was found to be less than 1-fold higher in E-vaccine recipients after 14 days than in placebo recipients receiving the same daily dose. No difference in mean serum total IgG and IgM antibodies to EBOV between the E- and CIBRV-vaccines was generic pharmacy franchise cost observed. Serum levels of VLP or VP40 IgG1 and IgM1 antibodies in patients with severe disease and persons clinical signs of EBOV infection, or serum IgM antibody titers to EBOV at the cutoff of neutralization with a neutralizing antibody in persons with EBOV immune globulin as measured by ELISA were not affected EBOV treatment. Efficacy of EBOV antigens in nonhuman primates To evaluate whether macaque kidney tissue can acquire and neutralize EBOV antigens with a similar degree of neutralizing activity as human kidneys, 100 CIBRV-vaccine-inoculated macaques were administered EBOV antigens by intradermal administration. The macaques were divided into 4 groups receiving injections of the CIBRV-vaccine, 5 days, 14 or 28 days after immunization with 1 booster dose of CIBRV-vaccine. No adverse events related to vaccine were described, but the mean titers of neutralizing antibody to the EBOV antigens were higher when treated monkeys received EBOV antigens 14 days after vaccination than if treated monkeys received EBOV antigens 5 days after vaccination. Efficacy of EBOV antigens in human volunteers In the clinical trial involving healthy adult volunteers between the ages of 36 and 50 years, the overall EBOV titers in 3 challenge groups were: 0.8-fold higher on day 14 after challenge with 0.1, 0.6, and 0.4 log unit titers, respectively; 1.7-fold higher on day 14 after challenge with the same titers of antibody to EBOV antigens as received in the CIBRV-vaccine group; and 4.5-fold higher on day 28 after challenge with 1 log unit titers of antibody to EBOV antigens as received in the CIBRV-vaccine group. Seroconversion to EBOV was confirmed in a subgroup of 14 young adults who received the same treatment regimen, i.e., intranasal administration of an EBOV-neutralizing T cell booster (20,000 U/kg) on day 14 after challenge. Most of these subjects (7 7) were subsequently